Integration of background genome variation to dissect complex cardiovascular phenotypes (697.5)

Human Genome Variation: Linking Genotypes to Clinical Phenotypes - Session Introduction

Now that major milestones have been reached by both the public and private sectors in the quest for the human genome sequence, the focus is shifting to the genetic variability of our species. Lying buried in human genetic variability is the source not only of all genetic disease, but the entire range of normal phenotypic variation, including susceptibilities to pathogens and environmental facto...

Using systems and structure biology tools to dissect cellular phenotypes

The Center for the Multiscale Analysis of Genetic Networks (MAGNet, http://magnet.c2b2.columbia.edu) was established in 2005, with the mission of providing the biomedical research community with Structural and Systems Biology algorithms and software tools for the dissection of molecular interactions and for the interaction-based elucidation of cellular phenotypes. Over the last 7 years, MAGNet ...

PHENOTYPIC INTEGRATION Studying the Ecology and Evolution of Complex Phenotypes

Exploiting induced variation to dissect quantitative traits in barley.

The identification of genes underlying complex quantitative traits such as grain yield by means of conventional genetic analysis (positional cloning) requires the development of several large mapping populations. However, it is possible that phenotypically related, but more extreme, allelic variants generated by mutational studies could provide a means for more efficient cloning of QTLs (quanti...

To dissect or not to dissect?